Coronary Artery Calcium Scoring Study (CAC)

“We know with improved detection and managemet, our patients are living longer following their cancer treatment. Now more than ever, it is important to ensure that they’re also living better.”

Dr Nina Stewart, co-lead of GenesisCare Foundation’s Coronary Artery Calcium Scoring (CAC Study)

The Program

Patients who have radiation therapy to the chest region often receive an unavoidable dose to the heart and, even small doses can increase the risk of cardiac disease in the future.1

It is this, in combination with cardiac toxicity from chemotherapy 2and shared risk factors between development of cancer and heart disease, that makes our patients vulnerable.

GenesisCare Foundation’s CAC Study, led by Doctors Yvonne Zissiadis and Nina Stewart, will identify whether the coronary artery calcium score, identified on thoracic radiation therapy planning CT scans, can be used and actioned to identify patients at high risk of cardiac events.

1 Ell P, et al. Curr Treat Ops Oncol. 2021; 10;22(8):70.

2 Jain D & Aronow W. Hosp Pract. 2019; 47(1):6-15.


Led by Doctors Yvonne Zissiadis and Nina Stewart the CAC study is a collaboration between cardiology and oncology research teams.

The purpose of the study is to identify patients at high risk of cardiac arrest, with the initial phase aiming to include 100 patients over the trial period.

By identifying patients at high risk of having a cardiac event, appropriate medical referrals can be put in place, creating a proven, and embedded referral pathway into cardio-oncology clinics for best possible life outcomes.

Programs & Impact

Prostate Spacing

Pancreatic Cancer


Small Grants

COVID-19 Response

Cancer Care Coordination