What is Dupuytren’s disease?

Dupuytren’s disease is a condition that causes excessive scar tissue within the fibrous fascia beneath the skin on the palm of the hand.1 In the early stages this is seen as lumps or cord-like thickenings.1 Over time contraction of the scar tissue can pull the fingers towards the palm, into a permanent bent position called a ‘contracture’, which can limit function of the hand.1

Woman painting with hand

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Diganosing Dupuytren’s disease

Diagnosing Dupuytren’s disease is usually done with a simple physical exam of your hand resting on a table. The doctor will test the flexibility, look at the appearance, and, along with history, a diagnosis will be established.4,5

Ultrasound and/or MRI may be warranted if surgery is a treatment option, as this establishes the thickness of the palmar tissues.4

Pair of hands

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Treatment options for Dupuytren's Disease

An initial assessment and discussion are important to help understand the uncertainties and alternative treatment options.

At the assessment, your specialist will discuss whether radiotherapy might be helpful for your condition, as well as side effects you may experience.

Note: You will need a referral from a GP or specialist for an assessment.

You should discuss treatment options with your referring doctor or specialist.

Treatment recommendations will depend on several factors, including the degree of impact the disease is having on your quality of life.1,2 Treatment may be offered for the correction of contractures (when the fingers are pulled into a bent position).1,2

Treatment options may include:1,2

  • Needle aponeuroromy – where the contracted tissue is divided so the finger can be stretched out again
  • Surgical fasciectomy
  • Radiation therapy - this may help prevent the progression of early-stage Dupuytren's disease, thereby reducing the need for invasive procedures
Photo with close-up of caregiver and patient holding hands

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Current clinical trial - DEPART

Radiation therapy has been used to help treat Dupuytren's contracture for many years. We are supporting the recruitment of patients with Dupuytren's contracture for a research study called 'DEPART'.

This study will assess patients with Dupuytren’s Disease in two settings:

  • those who have early-stage disease (no flexion contractures),
  • those who have late-stage disease requiring a straightening procedure to correct flexion contractures.

The trial is aimed at assessing how effective radiation therapy is at preventing the progression or recurrence of contractures. The trial is being run at select centres across the country:

For further information regarding this trial, please click here.

Or contact us at: GC-Depart@genesiscare.com

Content reviewed by

Review Date: October 2024

Prof Jarad Martin

MBChB BSc PhD DMed, FRANZCR GAustMS

Radiation Oncologist