SHERLOCK Protocol number: CTC 0377 / TOGA 21/011

Phase 2 trial of sotorasib in combination with carboplatin-pemetrexed and bevacizumab-biosimilar as first line treatment for advanced non-squamous non-small cell lung cancer with KRAS G12C mutation.

Trial overview


Lung cancer

Eligibility criteria


  • Adults, aged 18 years and older, with either:
     a) newly diagnosed, treatment naïve metastatic (Stage IV) non-squamous NSCLC, or
     b) recurrent non-squamous NSCLC with no disease progression for at least 6 months following prior curative lung surgery and (neo)adjuvant chemotherapy, or prior curative concurrent chemoradiotherapy and immunotherapy maintenance, for non-resectable stage III cancer.
  • Presence of KRAS G12C mutation in tumour tissue
  • Sufficient tumour tissue should be available for molecular profiling by Next Generation Sequencing (NGS) or results available from molecular profiling of tumour tissue by NGS. If there is insufficient tissue for NGS testing, a repeat biopsy is strongly recommended. Acceptable platforms include, but are not limited to: FoundationOne Tissue CDx, Illumina TruSight Oncology 500 (TSO500)
  • Measurable disease according to RECIST 1.1. Lesions previously irradiated are not considered measurable unless they have unequivocally progressed after radiation.
  • ECOG performance status of 0 or 1
  • Adequate organ function

Key Exclusion Criteria:

  • Previous treatment with sotorasib, or KRAS G12C specific inhibitor, or pan-KRAS inhibitor
  • Concurrent driver mutation (including EGFR, ALK, ROS1, BRAF) where an approved targeted therapy is available
  • Mixed histology with any small cell or squamous component
  • Evidence of active bleeding or bleeding risk
  • Significant  cardiovascular  disease, peripheral  vascular  disease  or  cerebrovascular  disease
  • Severe infection within 4 weeks prior to registration including, but not limited to hospitalisation for management of infection, bacteraemia or sepsis.
  • Spinal  cord  compression,  symptomatic  and  unstable  brain  metastases,  except  for  those  participants  who  have  completed  definitive  therapy,  are  not  on  steroids  equivalent  to  oral  prednisone of > 10 mg/day, and have a stable neurological status for at least 2 weeks after commencement  of  the  definitive  therapy.  Participants  with  untreated  asymptomatic  brain  metastases can be eligible for inclusion if immediate definitive treatment is not indicated
  • Life expectancy of less than 3 months


Study details

The new drug, sotorasib, is a tablet treatment which is targeted against the KRAS G12C gene mutation. Early results show that sotorasib is moderately active when given alone. The effectiveness of sotorasib might be increased when given in combination with other anti-cancer drugs. This study will investigate whether sotorasib used in combination with two chemotherapy drugs (called carboplatin and pemetrexed) and bevacizumab (which improves anti-cancer drug delivery), can result in better outcomes. The combination of carboplatin-pemetrexed-bevacizumab is a proven treatment for NSCLC.

Further information

Please click here for more information


Thank you for submitting.

We will be in touch within 24 hours

An unexpected error has occurred.

You will need to complete the form again, sorry for the inconvenience.

How can we help?

If you have a medical emergency please call 000. If you have an urgent request and would like to speak to our staff, please contact one of our centres directly.

* Indicates a required field.