Review Date: July 2025
- Patients
- Benign disease services
- Osteoarthritis
What is osteoarthritis?
What is osteoarthritis?
Osteoarthritis can significantly impact quality of life, limiting mobility and causing persistent discomfort.
Osteoarthritis is a degenerative joint disease that occurs when the protective cartilage that cushions the ends of the bones gradually wears away. This leads to joint pain, swelling, stiffness, and reduced mobility in the affected joints.
Osteoarthritis can affect any joint in the body, but it most commonly impacts the knees, hips, hands, spine, and feet. Less frequently, it can involve the shoulders and ankles, particularly after injury or repeated stress on the joint.1
LDRT for osteoarthritis
With its anti-inflammatory properties, long-lasting pain relief, and suitability for older adults or people who may not be candidates for surgery, LDRT is a safe and practical option for the management of osteoarthritis.
- Bridging therapy: LDRT can provide temporary assistance buying time and potentially helping patients avoid or delay surgery – while easing joint pain and stiffness.
- Non-surgical relief: LDRT is a non-surgical treatment that may help reduce inflammation and manage joint pain in some people with osteoarthritis.
- Symptom relief: Some people experience sustained symptom relief, which may delay the need for more invasive procedures like joint replacement.
- Evidence based: LDRT is supported by international research and delivered by qualified professionals, under strict medical guidelines and personalised care planning.
Osteoarthritis symptoms often develop slowly and worsen over time. They may vary depending on the joint affected, but commonly include:2
- Joint pain, especially during or after movement
- Stiffness, particularly in the morning or after inactivity
- Swelling around the joint
- Reduced flexibility or difficulty moving the joint through its full range
- A grating or cracking sensation during movement (called crepitus)
- Tenderness when pressing on or around the joint
- Bone spurs, which may feel like hard lumps around the joint
These include:3, 4, 5
- Aging: Cartilage naturally breaks down with age
- Joint injury: A previous injury, such as a fracture or ligament tear, can increase the risk of osteoarthritis
- Genetics: A family history of osteoarthritis may increase the likelihood of developing the condition
- Obesity: Extra body weight puts added pressure on joints, especially the knees, hips, and lower back
- Overuse: Repetitive movements or physical strain—common in some jobs or sports—can wear down joints over time
- Gender: Women are more likely than men to develop osteoarthritis
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Diagnosis
Diagnosis

If you’re experiencing joint pain or stiffness, your doctor may assess whether osteoarthritis is the cause. This usually involves a physical examination and discussion of your medical history.
Tests are not always needed to diagnose OA, however, you may be referred for tests such as:
- X-Ray: To look for signs of osteoarthritis, such as joint space narrowing, bone spurs, or changes in bone shape
- Blood tests: To rule out other types of arthritis, such as rheumatoid arthritis
- MRI scans: In the instance that more detailed images of soft tissue (like cartilage or ligaments) are needed6
Treatment options
Treatment options
Low-dose radiation therapy (LDRT) for osteoarthritis
While traditional treatments like medications, physical therapy and surgery remain as options, LDRT is a non-invasive alternative for patients seeking effective relief without the risks or recovery time associated with surgery.7
LDRT is a non-surgical treatment option that may help relieve pain, reduce stiffness, and improve movement in people with osteoarthritis.
Although radiation therapy is best known for treating cancer, research has shown that very low doses of radiation can have anti-inflammatory effects—making it a promising option for managing joint pain caused by osteoarthritis. 8-10
LDRT uses low doses of high energy x-ray beams, delivered from a machine called a linear accelerator (linac), to target the affected joint from outside the body The linac delivers a controlled dose of radiation to a precisely targeted area of the body, aiming for an anti-inflammatory effect on joints affected by osteoarthritis.

Our understanding of osteoarthritis has changed — it's no longer viewed as simply 'wear and tear'. Research now highlights the role of inflammation and the immune system in joint changes, including the breakdown of cartilage. Activated immune cells within our joints release pro-inflammatory factors that drive cartilage breakdown.
LDRT has shown promise in calming the immune response in the affected joint/s.7,-10
- It reduces inflammation, which may ease pain and swelling
- It may slow the breakdown of cartilage by lowering the activity of certain immune cells
- Over time, this may help improve joint function and delay the need for medication, physical therapy and more invasive treatments, such as surgery
Before your treatment begins, you will have an initial consultation with a radiation oncologist. During this appointment, the doctor will:
- Review your medical history
- Discuss your general health
- Explain your treatment options
- Talk through the treatment process
- Outline any potential side effects of radiation therapy11, 12
At the end of your appointment, a simulation scan will be arranged. This will help your treatment team plan your therapy and ensure it targets the correct area with precision.
Once the scan is complete it may take some time for your radiation therapy planning team to design your treatment.
When treatment begins you will come in for appointments, usually once a day from Monday to Friday. Each session takes around 15 minutes, although the exact number and length of treatments will be confirmed by your radiation oncologist.
During each visit, radiation therapists will position your body, so it matches the setup used in the simulation scan. This ensures that the radiation is delivered safely and accurately to the treatment area.11, 12
Like any medical treatment, radiation therapy can be associated with side effects.11, 12 Your radiation oncologist will discuss potential side effects you may experience prior to commencing treatment.
If you have any questions or concerns about side effects, please talk to a member of your care team.
Help is here
At GenesisCare, our experienced doctors offer low-dose radiation therapy (LDRT) to help manage a range of non-cancerous conditions. Contact us to learn more or schedule a consultation with one of our radiation oncologists.
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Find out more about GenesisCare's treatment options for benign conditions
Support services
Support services
Content reviewed by
Professor Jarad Martin
MBChB BSc PhD DMed, FRANZCR GAustMS
Radiation Oncologist
Maitland (Oncology) +1

Prof Michael Chao
MBBS (Hons) FRANZCR AFRACMA DMedSc
Radiation Oncologist
Peninsula Private Hospital +2

- Arthritis Australia. (2024). Osteoarthritis. https://arthritisaustralia.com.au/types-of-arthritis/osteoarthritis/ [Accessed July 2025]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases. (2023). Osteoarthritis. https://www.niams.nih.gov/health-topics/osteoarthritis [Accessed July 2025]
- NPS Medicinewise. (2021). Osteoarthritis, explained. https://www.nps.org.au/consumers/osteoarthritis-explained [Accessed July 2025]
- Victorian Department of Health. (2024). Better Health: Osteoarthritis. https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/osteoarthritis [Accessed July 2025]
- Dove, A. P., Cmelak, A., Darrow, K., McComas, K. N., Chowdhary, M., Beckta, J., & Kirschner, A. N. (2022). The use of low-dose radiation therapy in osteoarthritis: a review. International Journal of Radiation Oncology* Biology* Physics, 114(2), 203-220.
- Healthdirect. (2024). Osteoarthritis. https://www.healthdirect.gov.au/osteoarthritis [Accessed July 2025]
- Hoveidaei, A., Karimi, M., Salmannezhad, A., Yasaman, T., Taghavi, S. P., & Hoveidaei, A. H. (2025). Low-dose Radiation Therapy (LDRT) in Managing Osteoarthritis: A Comprehensive Review. Current Therapeutic Research, 100777.
- Fazilat-Panah, D., Javadinia, S. A., Shabestani Monfared, A., Attarian, F., Babaei, M., Yousefghahari, B., ... & Fallah Tafti, H. (2025). Effects of low dose rate radiotherapy on pain relief, performance score, and quality of life in patients with knee osteoarthritis; a double-blind sham-controlled randomized clinical trial. International Journal of Radiation Biology, 101(5), 541-548.
- Makarova, M. V., Valkov, M. Y., & Grjibovski, A. М. (2023). Orthovoltage x-ray therapy significantly reduces disability risk in knee osteoarthritis patients: A decade-long cohort study. rheumatology, 3(4), 7.
- Koneru, B. N., Sick, J., Shaikh, H., Spengler, H., Small, W., & Shaffer, R. (2025). Low Dose Radiotherapy for Osteoarthritis: A Retrospective Single Institution Analysis of 69 Patients and 168 Joints. International Journal of Radiation Oncology* Biology* Physics.
- Cancer Council. (2024). Understanding Radiation Therapy. https://www.cancer.org.au/assets/pdf/understanding-radiation-therapy-booklet [Accessed July 2025]
- eviQ. (2018). A guide for radiotherapy. https://www.eviq.org.au/getmedia/f6db4d48-25d9-44f9-a74b-bba0014d04d1/3366-eviQ-Patient-Information-Guide-to-radiotherapy-V6.pdf [Accessed July 2025]
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This website is provided for information purposes only. Nothing on this website is intended to be used as medical advice, or to diagnose, treat, cure or prevent any disease. It should not be used as a substitute for your own health professional's advice. Any medical procedure or treatment carries risks. Before proceeding with treatment, you should discuss the risks and benefits of the treatment with an appropriately qualified health practitioner. Individual treatment outcomes and experiences will vary.