Heart Failure and Cardiac Resynchronisation Therapy

Study title





A significant number of patients with heart failure implanted with a Cardiac Resynchronisation Therapy (CRT) device fail to respond to therapy. The cause of this non-response is yet to be determined.   

The purpose of this study is to assess the pattern of electrical wiring of the heart, identify the variations seen in individuals with heart failure and their response to CRT. This study will also evaluate the link of CRT response to septal scar (heart scar tissue) and patterns of electrocardiogram (ECG). 

Eligibility criteria

To be considered for the study you must meet the following criteria: 

  • 18 years of age or older 
  • Undergoing implantation of a Cardiac Resynchronisation Therapy (CRT) device under standard indications 
  • Treated with optimal pharmacological therapy for a minimum of 4 weeks prior to the implant procedure 
  • Have an electrocardiogram (ECG) showing sinus rhythm (normal heart rhythm) 
Study details

Your participation in this study would be for approximately12 months.   

You will need to attend the clinic for an initial assessment, including blood test, ECG, 6-minute walk test and cardiac MRI.  

You will then have your CRT device implanted and may be required to stay in hospital overnight. You will then be seen in-clinic at 3, 6 and 12 months. The purpose of these visits is to check the status of your implanted CRT device and identify whether you are responding to CRT.  

You will be reimbursed for any study-related travel and expenses. 

Sign up for this clinical trial below.