Connective Tissue Disorders

Study title





This study will assess patients with Dupuytren’s Disease in two settings: those who have early stages of the disease, and those who have progressive flexion contractures. It is the first trial of its kind and aims to assess safety and efficacy in the use of radiotherapy in both settings.

Eligibility criteria

To be considered for this study you must meet the following criteria: 

  • over 30 years of age 
  • diagnosed with Dupuytren’s contracture 
  • available and willing to participate in 5 years of follow-up 
  • eligible to be treated using radiotherapy 
Study details

This is a randomised study and your participation in this study would be approximately 5 years. 

Patients randomized to the treatment arm will receive 10 fractions of radiotherapy (treatment arm)  

Patients randomized to the observation arm will be followed up with their hand therapist as per standard of care. 

You will be required to attend clinic visit approximately every 6-12 months and be required to complete Quality of life questionnaires throughout the study 

Further information