SUCCOUR MRI SUB-STUDY
To evaluate if treatment with two cardioprotective medications reduces the risk of developing heart failure in participants currently undergoing chemotherapy
To be considered for the study you must meet the following criteria:
Be about to undergo treatment (or received ≤3 cycles) of anthracycline-containing chemotherapy AND ≥1 of:
a. Trastuzumab OR
b. Tyrosine kinase inhibitors OR
c. Cumulative anthracycline dose >450 mg/m2 OR
d. Prior treatment with anthracycline or chest-directed-radiotherapy for cancer OR
e. Heart failure risk factors, including ≥1 of:
- Age ≥65 years old
- Prior cardiac injury (e.g. heart attack)
Your participation in this study would be for approximately 1 year.
You will need to attend the clinic for an initial assessment, including medical history and physical examination, blood tests, ECG, echocardiogram, cardiac MRI and completing questionnaires regarding physical symptoms and quality of life.
You will then be reviewed every 3 months, up to 12 months. (i.e. 5 visits in total, including baseline visit). Tests performed at review would include an echocardiogram and completing questionnaires regarding physical symptoms and quality of life.
You will be reimbursed for travel and study related expenses.