Heart Disease
Heart Disease Ongoing 2019 Heidelberg VIC, Bundoora VIC, Mulgrave VIC, Berwick VIC, Ringwood VIC, Doncaster East VIC, Murdoch WA, Auchenflower QLD

SUCCOUR MRI SUB-STUDY

To evaluate if treatment with two cardioprotective medications reduces the risk of developing heart failure in participants currently undergoing chemotherapy.

Trial overview

Disease
Cardiovascular disease & care
Topic
SUCCOUR MRI SUB-STUDY
Eligibility criteria

To be considered for the study you must meet the following criteria:

Be about to undergo treatment (or received ≤3 cycles) of anthracycline-containing chemotherapy AND ≥1 of the following:

a. Trastuzumab in breast cancer with the HER2 mutation OR

b. Tyrosine kinase inhibitors OR

c. Cumulative anthracycline dose >450 mg/m2 OR

d. Chest radiotherapy (left-sided) OR

e. Prior treatment with anthracycline or chest-directed radiotherapy for cancer OR

f. Increased risk of heart failure (age ≥65 years old, type II diabetes, hypertension, prior cardiac injury, e.g. heart attack)

g. Patients who have completed anthracycline treatment but will continue to be treated with other cardiotoxic treatments such as trastuzumab, tyrosine kinase inhibitors or left-chest radiotherapy during the course of surveillance

Study details

Your participation in this study would be for approximately 1 year.

You will need to attend the clinic for an initial assessment, including medical history and physical examination, blood tests, ECG, echocardiogram, cardiac MRI and completing questionnaires regarding physical symptoms and quality of life.

You will then be reviewed every 3 months, up to 12 months. (i.e. 5 visits in total, including baseline visit). Tests performed at review would include an echocardiogram and completing questionnaires regarding physical symptoms and quality of life.

You will be reimbursed for travel and study related expenses.

Sign up to this clinical trial here.

Physicians

Dr Leighton Kearney

BMedSci MBBS (Hons) PhD FRACP

Cardiovascular Imaging Specialist

Bundoora (Cardiology)

A/Prof Piyush Srivastava

MBBS FRACP FCSANZ FESC FACC FAHA

Cardiovascular Imaging Specialist

Works at 2 centres.

Dr Ben Fitzgerald

MBBS, FRACP, FCSANZ

Cardiovascular Imaging Specialist

Works at 4 centres.
Location