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  • Gynaecological Cancer
  • Cervical cancer

Introduction

Cervical cancer

Learn more about cervical cancer including types, symptoms, risk factors, steps to diagnosis and potential treatment options.

What is cervical cancer?

What is cervical cancer?

The cervix is the lower part of the uterus that connects to the vagina.1 During pregnancy, the cervix helps keep the baby in the uterus until birth.1

Cervical cancer occurs when abnormal cells develop in the lining of the cervix and grow uncontrollably, forming a tumour.2–4 Anyone with a cervix can develop cervical cancer. This includes people who identify as heterosexual, lesbian, gay, bisexual, or transgender.3,5

There are two main types of cervical cancer:2-4

  • Squamous cell carcinoma (SCC): The most common type of cervical cancer. It usually begins in the thin, flat cells lining the outer surface of the cervix.
  • Adenocarcinoma Develops from glandular cells on the inner surface of the cervix.3,6 This type can be more difficult to detect, as it starts higher in the cervical canal and may not always be reached during routine cervical screening tests.3,6

Cervical cancer may cause one or more of the following symptoms:3,4

  • Vaginal bleeding between periods, during or after sex, or after menopause
  • Pain during sex
  • Pelvic pain
  • Heavier or longer-lasting periods
  • Changes in vaginal discharge, such as unusual colour, smell, or volume

These are some of the more commonly reported symptoms of cervical cancer.4,7 Symptoms can also be caused by other conditions. If you notice anything unusual or have concerns, it’s important to speak with your doctor.

Cells in the cervix don’t suddenly become cancerous, but instead usually change gradually over time.7

Some known risk factors may contribute to the development of cervical cancer, particularly exposure to the human papillomavirus (HPV).2,4,6

HPV is passed through skin-to-skin contact, most commonly during sexual activity.2 Different strains of HPV carry different levels of risk.2 Not everyone who is exposed to HPV will develop cervical cancer, but almost all cases of cervical cancer are linked to HPV.8,9

While HPV exposure is a key risk factor for cervical cancer, it is not the only factor that needs to be considered.1,8 Other risk factors include::2,3

  • smoking
  • long-term use of the contraceptive pill (associated with a small increased risk)
  • a weakened immune system
  • people whose mother was given diethylstilbestrol (DES) during pregnancy, an artificial form of oestrogen used between 1939 and 1971

There is a vaccine available to protect against the HPV types most commonly linked to cervical cancer.8 Your doctor can discuss how HPV is related to cervical cancer risk8 and advise on how to access the HPV vaccine through the National Immunisation Program.

An ethnic woman wearing a headscarf and fighting cancer sits on the couch with her mother. She is in the foreground and her mom is behind her, with her arm wrapped around in an embrace, and they're both looking out the window in a quiet moment of contemplation.

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Diagnosis

Diagnosing cervical cancer

Currently, the most effective way to identify changes that may lead to cervical cancer is through a cervical screening test (previously known as a Pap smear).3,4 In Australia, screening is free and recommended every five years for people aged 25 to 74.2

If your screening test shows abnormal results, your GP may refer you to a specialist for further investigations, which may include:3,4

  • Colposcopy – a magnifying instrument called a colposcope is used to examine the cervix more closely
  • Biopsy – during a colposcopy, a small tissue sample may be taken and sent for laboratory testing

If anything unusual is found, your doctor will explain what the results mean and discuss the next steps.

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Treatment options

Treatment options for cervical cancer

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There are various treatment options available, and your doctor will determine the most suitable approach based on your diagnosis and individual circumstances.10,11 

Factors that may influence the recommended treatment approach include the stage of the cancer, your age, and whether you wish to have children.11

Treatment options for cervical cancer may include:4,10-12

Chemotherapy is an approach to cancer therapy which involves the administration of medicine, usually orally or injection, which is intended to kill cancer cells or minimise their growth and spread. Chemotherapy can be used in conjunction with other cancer treatments.

Chemotherapy

Radiation therapy may be offered in the early stages of cancer treatment or after it has started to spread. There are different radiation therapy techniques that may be suitable for different cancer types at different stages.

Radiation Therapy

Surgical intervention can be used in some cases to remove the cervix, uterus, and surrounding tissue. Your doctor will consider whether surgical intervention is appropriate for you.

Targeted therapy uses medications that are designed to target and help kill or slow the growth of cancer cells.

Targeted Therapy

Treatment side effects

All cancer treatments can cause side effects, and the type and severity will vary between individuals. You should ask your doctor for detailed information about the possible side effects of any treatment recommended for you.

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Support services

Support services

Cancer Council Australia

Australia's leading cancer charity, Cancer Council aims to lead a cohesive approach to reduce the impact of cancer.

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Australian Gynaecological Cancer Foundation (AGCF)

AGCF funds research into all types of gynaecological cancers to improve screening, treatment, and outcomes for women.

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Australian Cervical Cancer Foundation (ACCF)

ACCF is the only consumer-focused cancer charity in Australia dedicated exclusively to preventing cervical cancer and to supporting all individuals impacted by a cancer in cervix and cervical abnormalities.

Visit website
  1. Evbuomwan, O., & Chowdhury, Y. S. (2023, May). Physiology, cervical dilation. In StatPearls. StatPearls Publishing. Retrieved July 2023, from https://www.ncbi.nlm.nih.gov/books/NBK539881/
  2. Choi, J., et al. (2023). Human papillomavirus and cervical carcinogenesis. Pathogens, 12(2), 298. https://doi.org/10.3390/pathogens12020298
  3. Cancer Council Australia. (2023, March). Cervical cancer. Retrieved July 2023, from https://www.cancer.org.au/cancer-information/types-of-cancer/cervical-cancer
  4. Burmeister, C. A., Khan, S. F., Schäfer, G., Mbatani, N., Adams, T., Moodley, J., & Prince, S. (2022). Cervical cancer therapies: Current challenges and future perspectives. Tumour Virus Research, 13, 200238. https://doi.org/10.1016/j.tvr.2022.200238
  5. Berner, A. M., Connolly, D. J., Pinnell, I., Wolton, A., MacNaughton, A., Challen, C., … Richards, C. (2021). Attitudes of transgender men and non-binary people to cervical screening: A cross-sectional mixed-methods study in the UK. British Journal of General Practice, 71(709), e614–e625. https://doi.org/10.3399/BJGP.2020.1105
  6. Teoh, D., Musa, F., Salani, R., Huh, W., & Jimenez, E. (2020). Diagnosis and management of adenocarcinoma in situ: a society of gynecologic oncology evidence-based review and recommendations. Obstetrics & Gynecology, 135(4), 869-878.
  7. Institute for Quality and Efficiency in Health Care. (2017, December). Cervical cancer: Overview. In InformedHealth.org. Retrieved July 2023, from https://www.ncbi.nlm.nih.gov/books/NBK279259/
  8. Australian Government, Department of Health. (2023, July). Human papillomavirus (HPV). Retrieved July 2023, from https://www.healthdirect.gov.au
  9. World Health Organization. (2022, February). Cervical cancer. Retrieved July 2023, from https://www.who.int/news-room/fact-sheets/detail/cervical-cancer
  10. National Comprehensive Cancer Network. (2021, October 26). NCCN clinical practice guidelines in oncology: Cervical cancer (Version 1.2022). Retrieved July 2023, from https://www.nccn.org
  11. Australian Government, Cancer Australia. (2022, September). Cervical cancer: Treatment options. Retrieved July 2023, from https://www.canceraustralia.gov.au
  12. Cohen, P. A., et al. (2019). Cervical cancer. The Lancet, 393(10167), 169–182. https://doi.org/10.1016/S0140-6736(18)32470-X

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Disclaimer:

This website is provided for information purposes only. Nothing on this website is intended to be used as medical advice, or to diagnose, treat, cure or prevent any disease. It should not be used as a substitute for your own health professional's advice. Any medical procedure or treatment carries risks. Before proceeding with treatment, you should discuss the risks and benefits of the treatment with an appropriately qualified health practitioner. Individual treatment outcomes and experiences will vary.

This website is provided for information purposes only. Nothing on this website is intended to be used as medical advice, or to diagnose, treat, cure or prevent any disease. It should not be used as a substitute for your own health professional's advice. Any medical procedure or treatment carries risks. Before proceeding with treatment, you should discuss the risks and benefits of the treatment with an appropriately qualified health practitioner. Individual treatment outcomes and experiences will vary.
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