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  • Patients
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  • Gastrointestinal Cancer
  • Stomach Cancer

Introduction

image

Stomach cancer

Learn more about stomach cancer, symptoms, diagnosis and potential treatment options.

What is stomach cancer?

What is stomach cancer?

Stomach cancer occurs when abnormal cells in the stomach area grow in an uncontrolled way.1,2 The stomach is part of the upper gastrointestinal (GI) tract, which forms part of the body’s digestive system.3

There are four types of stomach cancer including:

  • Gastric adenocarcinoma (also known as gastric cancer) starts in the glandular cells that line the inner layer of the stomach wall (called the mucosa). Gastric adenocarcinoma is the most common type of stomach cancer in Australia.2,4
  • Gastrointestinal stromal tumours (GIST) are regarded as being rare cancers that start in the connective (interstitial) tissue in the stomach wall.5
  • Lymphomas are regarded as being rare cancers of the lymph system that sometimes are found in the wall of the stomach.6
  • Carcinoid tumours are regarded as being rare cancers that start in the hormone-making cells of the stomach.7

Stomach cancer may not cause symptoms in the early stages and is often diagnosed when it’s more advanced. Common stomach cancer symptoms may include:1,2

  • Indigestion or heartburn, particularly if it is getting worse 
  • Difficulty or pain when swallowing, or also a sense of choking when swallowing, which is called dysphagia 
  • Feeling full or bloated, especially after only eating a small amount 
  • Loss of appetite 
  • Unexplained weight loss
  • Nausea, or vomiting, with or without blood 
  • Black or bloody stools 
  • Pain in the upper abdomen, which may occur when eating 
  • Swollen abdomen caused by a build-up of fluid 
  • Feeling tired, without reason 
  • Anaemia

It's important to note that these symptoms do not necessarily mean that you have stomach cancer. If you are concerned or have further questions, please make an appointment with your GP or specialist.

There are no clear causes for stomach cancer, however there are a range of factors that may increase the potential risk of diagnosis. These risk factors may include:1,2

  • Having a chronic stomach condition, such as, Helicobacter pylori (H. pylori) infection, chronic gastritis (stomach inflammation) or gastric polyps (non-cancerous growths on the inner lining of the stomach) 
  • Being older
  • Low levels of red blood cells 
  • A partial gastrectomy (stomach removal) to treat non-cancerous conditions 
  • Eating a high salt diet including smoked or pickled foods, and low in fruit and vegetables
  • Smoking tobacco 
  • Drinking excessive amounts of alcohol 
  • Overweight or obese 
  • Family history of stomach cancer or gastrointestinal disorders.

It is recommended to make an appointment with your GP or specialist, if you are concerned or have questions pertaining to risk factors for stomach cancer.

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Diagnosis

Diagnosing stomach cancer

There are a few different tests that may be undertaken to diagnose stomach cancer, including:1,2

  • Physical examination
  • Endoscopy: this is an examination of the inside of the stomach and other parts of the upper digestive system, which is done using an endoscope.
  • Biopsy: this involves a tissue sample (known as a biopsy) being taken from the stomach wall, for further examination under a microscope. Generally, a biopsy is taken during an endoscopy.

If you are diagnosed with stomach cancer, you may have further tests which aim to help understand how far the cancer has progressed. These are called staging tests, and may include:1,2,8

  • Imaging tests: such tests may include an endoscopic ultrasound, computerised tomography (CT) scan, positron emission tomography (PET-) CT scan or a magnetic resonance imaging (MRI). The objective of imaging-based tests is to understand more about the size and location of the tumour. Imaging tests may also help to determine if the cancer has spread to your lymph nodes or elsewhere.
  • Laparoscopy: this is a surgical procedure that may be used to look inside the abdomen to detect if the tumour has spread.
A pre-school age girl helps her dad pick out veggies in the produce section at the grocery store. He is holding her next to the produce and she is picking out eggplant.

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Treatment options

Treatment options for stomach cancer

Your treating doctor will discuss the most appropriate option(s) for treatment with you. The options suggested to you may depend upon the stage of the cancer, your overall health, symptom severity, and your personal preference.

One of the treatment options suggested to treat stomach cancer may be surgery9,10 along with other options that are listed below.1,2

One of the treatment options suggested to treat stomach cancer may be surgery, with usually two types of surgical treatment suggested:9,10

Endoscopic resection - This can remove early-stage tumours in the stomach. It is done using an endoscope.

Gastrectomy - Surgery to remove all or part of the stomach is called a gastrectomy. The surgeon aims to remove as much of the tumour as possible, including some healthy tissue and lymph nodes, to help reduce the risk of the cancer recurring. 

There are two types of gastrectomy: partial gastrectomy and total gastrectomy.

Chemotherapy is an approach to cancer therapy which involves the administration of medicine, usually orally or by injection, which is intended to kill cancer cells or minimise their growth and spread. Chemotherapy can be used in conjunction with other cancer treatments.

Chemotherapy

Targeted therapy refers to treatment with medicines that are designed to specifically attack cancer cells without harming normal cells. These types of medicines affect the way that cancer cells grow, divide, repair themselves or interact with other cells.

Targeted Therapy

Radiation therapy may be offered in the early stages of cancer treatment, or after it has started to spread. There are different radiation therapy techniques which may be suitable for different cancer types at different stages.

Radiation Therapy

Immunotherapy is a type of treatment that is intended to help your own immune system fight cancer. There are different types of immunotherapy for cancer that work in different ways.

Immunotherapy
elderly man with computer

All cancer treatments may have side effects, yet the type and severity of side effects will vary between individuals[1] .11 You can ask your doctor for detailed information about the side effects which you may experience with any treatment recommended for you.

Recommendations to help you stay well during treatment:12
  • Get as much rest as possible
  • Aim for a wholefood, varied diet, and we also encourage you to think about eating foods that interest you rather than what you think you should eat
  • Appetite changes are common, and you may experience taste changes or nausea. Help manage this by eating small, frequent snacks and avoiding smells that make you nauseous
  • Drink lots of water
  • Reach out to support groups and others who have had cancer treatment
  • Record your side effects in a diary or journal
  • Speak to your doctor about incorporating some gentle exercise into your weekly routine
  • It is important to acknowledge when you are fatigued and rest when you need to
  • Ask for and accept help from family, friends and neighbours
  • Be open with employers about your treatment and discuss flexible working options if you need them

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Support services

Support services

Cancer Council Australia

Australia's leading cancer charity, Cancer Council aims to lead a cohesive approach to reduce the impact of cancer.

Visit website

Australian Cancer Research Foundation

ACRF funds cutting-edge cancer research by providing scientists with advanced technology and infrastructure.

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GI Cancer Institute

GI Cancer Institute is the community-facing brand of the Australasian Gastro-Intestinal Trials Group, raising awareness and providing patient resources.

Visit website
  1. Cancer Council Australia [website]. What is Stomach Cancer? Updated Sept 2023 [cited Sept. 2023]. Access: https://www.cancer.org.au/cancer-information/types-of-cancer/stomach-cancer#
  2. Mukkamalla S.K.R, et al.StatPearls [Internet]. Treasure Island (FL): Gastric Cancer. Page last updated Feb 2023 (cited Oct. 2023). Access from: https://www.ncbi.nlm.nih.gov/books/NBK459142/
  3. Hsu, Met al.. StatPearls [Internet]. Treasure Island (FL): Physiology, stomach. Page last updated July 2023 (cited Oct. 2023). Access from: https://www.ncbi.nlm.nih.gov/books/NBK535425/
  4. Machlowska, J., et al. Int J Mol Sci. 2020; 21(11): 4012.
  5. Von-Mehren, M & Joensuu, H. J Clin Oncol. 2018; 36(2): 136–143.
  6. Herlevic, V & Morris, J.D. Gastric lymphoma: StatPearls [Internet]. Treasure Island (FL): Gastric Cancer. Page last updated Nov. 2023 (cited Jan. 2024). Access from: https://www.ncbi.nlm.nih.gov/books/NBK567799/
  7. Cingam, S.R., et al. StatPearls [Internet]. Treasure Island (FL): Carcinoid tumour. Page last updated Sept. 2022 (cited Jan. 2024). Access from: https://www.ncbi.nlm.nih.gov/books/NBK448101/
  8. Zhang, Y & Yu, J. Diagn Interv Radiol. 2022; 26(3): 176–182.
  9. Kim, G.H., et al Gastrointest Endoscopy Clin N Am 31 (2021) 563–579
  10. Marsh, A.M., et al. StatPearls [Internet]. Treasure Island (FL): gastric Resection. Page last updated July 2023 (cited Jan. 2024). Access from: https://www.ncbi.nlm.nih.gov/books/NBK560760/
  11. Cancer Council Australia [website]. Cancer Side effects? [cited Jan. 2024]. Access: https://www.cancer.org.au/cancer-information/cancer-side-effects
  12. Cancer Council Australia [website]. Nutrition for People Living with Cancer. Page last updated July 2022 [cited Jan. 2024]. Access: https://www.cancer.org.au/assets/pdf/nutrition-and-cancer-booklet
  13. Cancer Council Australia [website]. Does cancer only casue physical changes? [cited Jan. 2024]. Access: https://www.cancer.org.au/iheard/does-cancer-only-cause-physical-changes
  14. Cancer Council Australia [website]. After a diagnosis. [cited Jan. 2024]. Access: https://www.cancer.org.au/cancer-information/after-a-diagnosis#

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Disclaimer:

This website is provided for information purposes only. Nothing on this website is intended to be used as medical advice, or to diagnose, treat, cure or prevent any disease. It should not be used as a substitute for your own health professional's advice. Any medical procedure or treatment carries risks. Before proceeding with treatment, you should discuss the risks and benefits of the treatment with an appropriately qualified health practitioner. Individual treatment outcomes and experiences will vary.

This website is provided for information purposes only. Nothing on this website is intended to be used as medical advice, or to diagnose, treat, cure or prevent any disease. It should not be used as a substitute for your own health professional's advice. Any medical procedure or treatment carries risks. Before proceeding with treatment, you should discuss the risks and benefits of the treatment with an appropriately qualified health practitioner. Individual treatment outcomes and experiences will vary.
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