Mr Lamb’s clinical focus is to deliver excellent and timely prostate cancer care to men referred to the team from the Oxford regional area, focussing on state-of-the-art diagnostics with multiparametric MRI and targeted transperineal biopsies, followed by robotic-radical prostatectomy (RARP) or indeed active surveillance where appropriate. Complimentary treatment modalities such as radiation or brachytherapy are provided by other members of the dedicated prostate cancer team. Mr Lamb has a particular interest in pushing the boundaries of minimal access surgery (MIS), for example to performing cytoreductive radical prostectomy in locally advanced or metastatic disease and RARP in fit, older men where such approaches are deemed safe and evidence-based.
Mr Lamb’s research goal is to provide a robust molecular platform for accurate decision-making in early stage prostate cancer. He has spent his scientific training investigating how individual genes or groups of genes have driven prostate cancer behaviour.
Mr Lamb’s PhD thesis investigated the role of HES6 as a transcriptional driver in castrate resistant prostate cancer – it was found that this single gene fundamentally changed the nature of prostate cancer cells. During this time, Mr Lamb was funded by the Cambridge Biomedical Research Centre (NIHR) and GlaxoSmithKline, and also by a Raymond and Beverly Sackler Studentship. Since then, he has been employing integrative genomics in prostate cancer risk stratification as well as disease modelling with patient derived xenografts.
Mr Lamb also has an interest in novel molecular imaging techniques such as 68Ga-PSMA PET/CT and their use in disease stratification and selection of patients for surgery. He is a local investigator for the ProMOTE, PART and TRoMbone studies.