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Dr Nick Coupe

  • B.Med Sci, MBBS (Hons), FRACP, MRCP, DPhil
  • Consultant Medical Oncologist


Awards received

  • Department of Oncology Clinical Research Training Fellow (phD) prize winner, 2017
  • CRUK funded Clinical Training Research Fellowship, 2015
  • Oxfordshire Health Services Research Committee (OHSRC) competitive research grant
  • John Harris Prize, Sydney University
  • Albert Hing Memorial Prize in Gynaecology, Sydney University

Clinical interests

  • Immunotherapy for the treatment of lung cancer and melanoma
  • Early and late phase clinical trials
  • Teaching
  • Education supervision for trainees

Publications & affiliations

  1. Fane M, Ecker B, Kaur A, Marino G, Alicea G, Coupe N, Douglass S, et al. sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients. Clin Cancer Res. 2020 Nov 1;26:5709–19.
  2. Eyre TA, Collins GP, Gupta A, Coupe N, Sheikh S, Whittaker J, et al. A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer. Cancer. 2019 Jan 1;125(1):99–108.
  3. Manoharan V, Lee S, Chong S, Yap J, Coupe N, Wilson R, et al. Serial imaging using [18F]Fluorodeoxyglucose positron emission tomography and histopathologic assessment in predicting survival in a population of surgically resectable distal oesophageal and gastric adenocarcinoma following neoadjuvant therapy. Ann Nucl Med. 2017 May;31(4):315–23.
  4. Lloyd-Lavery A, Hodgson T,Coupe N, Bond S, Shah K, Espinosa O, Payne MJ, Middleton MR, Matin RN. Delayed oral toxicity from long-term vemurafenib therapy. Br J Dermatol. 2016 May;174(5):1159-60
  1. Coupe N, Gupta A, Lord SR. Early phase cancer clinical trials: design, ethics and future directions. Br J Hosp Med (Lond). 2015;76(7):409-13
  1. Coupe N, Corrie P, Hategan M, Larkin J, Gore M, Gupta A, et al. PACMEL: a phase 1 dose escalation trial of trametinib (GSK1120212) in combination with paclitaxel. Eur J Cancer. 2015;51(3):359-66

Professional memberships

  • General Medical Council
  • Royal Australasian College of Physicians
  • Royal College of Physicians

Dr Nick Coupe's reviews