What is vulval cancer?

Vulval cancer starts in the vulva. The vulva is the name for the genitals outside the opening of the vagina. The most common place for vulval cancer to start is the skin of the outer lips (labia majora) or inner lips (labia minora). It can also affect the clitoris. 

There are several types of vulval cancer. The most common type is squamous cell carcinoma, which starts in the outer layer of skin cells. Other types include verrucous carcinoma, melanoma and basal cell carcinoma.

Vulval cancer is rare, with around 1,400 people in the UK diagnosed with it each year. Anyone with a vulva can get vulval cancer, but it mostly affects women over 65. Diagnosing the condition early often allows for more treatment options and better outcomes.

Risk factors for vulval cancer

Risk factors increase the chances of getting vulval cancer. But you can get the condition even without risk factors – never ignore symptoms.

  • You are over 65
  • You’ve had a chronic HPV infection
  • You have a weakened immune system
  • You smoke
  • You have certain vulval skin conditions 

Vulval skin conditions that are linked to cancer include lichen planus, lichen sclerosus, Paget’s disease and precancerous skin changes.

Prevention of vulval cancer

It’s not always possible to prevent vulval cancer. 

You can take steps to reduce the risk of vulval cancer:

  • Get the HPV vaccine
  • Use condoms to lower the risk of getting HPV
  • Stop smoking

You can also reduce the chances of being diagnosed with a later stage of vulval cancer by checking your vulva, and getting treatment for any precancerous changes.

Early signs and symptoms

Vulval cancer may not always cause symptoms. It can help to know how your vulva usually looks and feels so you can spot early changes.

Vulval cancer symptoms include:

  • Itching that does not go away
  • A sore, painful or tender vulva
  • Raised or thick patches, which may be red, white or dark
  • A lump or a wart-like growth
  • Burning pain when urinating
  • Bleeding, bloody discharge or spotting
  • An open sore
  • A mole that changes shape, size, or colour 

When to see a doctor

If you notice any possible signs of vulval cancer, speak to your doctor. It may not mean cancer, but symptoms should always be checked to allow early treatment if needed.

Some people find it embarrassing to discuss genital symptoms. Your doctor is there to help, and your health is the most important aspect. 

What causes vulval cancer?

It’s not always known what causes vulval cancer. But there are risk factors that increase your chances of getting the condition. These include age, HPV infections, certain skin conditions, and smoking.

Diagnosis and tests

How is vulval cancer diagnosed?

 

If you have possible signs of vulval cancer, you should book an appointment with your GP, who can assesses your symptoms and, refer you to a specialist for further assessment.

If a biopsy is required, a sample from your vulva will be taken to look at under a microscope for cancer cells. If it shows cancer, you’ll have more diagnostic tests to check whether the cancer has spread.

These include:

  • Cervical screening
  • Cystoscopy to check the bladder
  • Proctoscopy to check the rectum
  • Imaging scans such as CT scanMRI scan, and ultrasound

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0808 304 2332

Stages of vulval cancer

The stage describes the cancer’s size and spread. This helps your doctor suggest the best treatment plan for your diagnosis.

Stage 1Early stage vulval cancer. The cancer is only in the vulva.
Stage 2The cancer has spread nearby to the lower vagina, lower urine tube (urethra), or lower anus.
Stage 3The cancer has spread nearby and to lymph nodes in the groin.
Stage 4Advanced or metastatic vulval cancer. The cancer has spread further, such as to the pelvic bone or lungs.

Vulval cancer staging can be confusing. Your doctor is always the best person to explain your cancer stage. 

Treatment overview

Treatment for vulval cancer typically depends on how big the cancer is, whether it’s spread and your general health. The main treatments are surgery, radiotherapy and chemotherapy.

How is vulval cancer treated?

Treatment for vulval cancer includes:

  • Surgery – the type of surgery you have will depend on how big your cancer is and how much of your vulva is affected
  • Radiotherapy – high-energy radiation beams are delivered to destroy cancer cells while doing as little harm as possible to healthy cells
  • Chemotherapy – anti-cancer (cytotoxic) drugs that destroy cancer cells
  • Targeted therapy – blocks processes that vulval cancer cells use to survive and grow
  • Immunotherapy   encourages your immune system to recognise and attack vulval cancer cells 

Skip ahead to learn more about our world-class treatments for vulval cancer at GenesisCare.

 

Vulval cancer treatment at GenesisCare

We’re the UK’s leading independent provider of private cancer care. By choosing us, you can be reassured that your treatment is managed by a team of specialists working together with you to design the best plan for your ovarian cancer diagnosis.

Our approach to world-class care for vulval cancer includes:

  • A personalised plan built around you
  • Treatment starting within days if needed
  • 14 outpatient cancer centres across the UK
  • State-of-the-art facilities specialising in advanced radiotherapy
  • Compassionate chemotherapy nurses available 24/7 by telephone
  • Integrative cancer care including wellbeing therapies and exercise medicine
  • Recognised by all leading private medical insurers and self-pay available

     

    We’re proud that so many patients rate our care as excellent as we help them through their cancer journey. Hear the unique experiences of people who have had their cancer diagnosis or treatment at GenesisCare in our patient stories section.

Call us today

0808 304 2332
0808 304 2332

Surgery at GenesisCare

Our cancer specialists have close relationships with top surgeons from local and nationally renowned hospitals. They’ll work with them and other gynaecological experts to decide the best course of treatment for you. This can be arranged conveniently at one of our partner hospitals. You can then continue your other treatments at GenesisCare.

We understand that vulval cancer surgery can feel worrying. You’ll be supported at every stage, from discussing the latest options with our leading consultants to psychological support and managing your recovery for the best possible outcomes.

Chemotherapy at GenesisCare

We offer many of the newest evidence-based drug therapies used to treat vulval cancer. Depending on the treatment, you may attend one of our private chemotherapy suites, staffed by specialist nurses.

Our compassionate nursing teams are available 24/7 on a dedicated on-call telephone service, and they can answer any queries during your treatment. They can also advise on side effects and symptoms and arrange appropriate medical care when needed.

Our centres have all received the Macmillan Quality Environment Mark to reflect the quality of care we provide for people living with cancer.

Radiotherapy at GenesisCare

At GenesisCare, we’re the leading independent provider of radiotherapy in the UK and offer world-class expertise, state-of-the-art facilities and advanced radiotherapy techniques.

Your journey is overseen by expert multidisciplinary teams (MDTs), consisting of oncologists, radiotherapists, and medical physicists. They collaborate closely to design a personalised treatment plan for you that ensures you get the best possible care.

We deliver radiotherapy using our latest-generation machines, built to deliver highly targeted and controlled radiation beams. The accuracy of these treatments, together with the expertise of our teams, helps our patients achieve the best possible outcomes.

Our leading consultants are experts in the latest radiotherapeutic techniques for vulval cancer, including stereotactic ablative radiotherapy (SABR). Focused high-energy radiation beams allow treatment in five or fewer sessions, often instead of surgery. If you’ve previously had radiotherapy to the pelvis, the precision of SABR can allow re-treatment.

Palliative care for vulval cancer

If your cancer is widespread to other parts of the body, it’s called advanced or If your cancer has spread to other parts of the body, it may be called advanced, metastatic or stage 4 vulval cancer. At GenesisCare, your specialist may recommend palliative drug treatment for advanced vulval cancer to reduce the size and progress of your cancer and ease pain and other symptoms.

Personalised medicine for vulval cancer

For some advanced cancers, we use specialist tests, such as liquid biopsy or genomic testing, to understand the genetic makeup of cancer cells. This helps us to identify which drugs are available to work against specific genetic mutations in your cancer to help start effective treatment without delay.

There may also be opportunities to access clinical trials for the newest drug treatments for vulval cancer.

Integrative cancer care at GenesisCare

We treat more than just your cancer, with a program of personalised integrative cancer care proven to improve cancer outcomes. This includes exercise medicine, sleep support and access to a wellbeing expert, plus holistic therapies such as counselling, acupuncture, massage and reflexology through our unique partnership with the Penny Brohn UK charity.

FAQs about vulval cancer

Reviewed by:

Dr Gemma Eminowicz

Consultant Clinical Oncologist

July 2025

Dr Gemma Eminowicz

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