Breast Cancer

HER2 REAL (D9673R00005)

A Multicountry, Multicentre, Noninterventional Retrospective Study to Describe the Real-world Treatment Patterns and Associated Outcomes in Patients With HER2-positive Unresectable or Metastatic Breast Cancer.

Trial overview


Breast Cancer

Eligibility criteria

  • Adult female or male patients =18 years old or ‘adults’ according to age of majority as defined by the local
  • regulations
  • Patient or next of kin/legal representative willing and able to provide written informed consent according to the
  • local regulations unless a waiver is granted by the local IRB/IEC/EC
  • Patients’ medical records showing diagnosis of HER2-positive unresectable or mBC (can be either de novo
  • advanced disease, progression or recurrence of previous early-stage HER2-positive BC) since the available date of TDM1
  • (Kadcyla) through reimbursement or patient access programme as a valid local treatment option or 01 January
  • 2017, whichever is earlier, and with availability of at least 12 months of follow-up data (from the date of diagnosis of
  • unresectable or mBC) in the medical records at the participating site, unless patient died within the first 12 months of diagnosis
  • Patients completing at least 2 LOTs for HER2-positive unresectable or mBC

Study details

This multicountry, multicenter, retrospective, non-interventional study involving patients diagnosed with HER2- positive unresectable or metastatic breast cancer mBC will be conducted to understand the demographic and clinico-pathological profile of the patients, diagnostic practices for human epidermal growth factor receptor 2 (HER2) status, current treatment landscape and sequencing of therapies, associated burden of toxicities with all lines of treatment (LOTs), and survival outcomes in the real-world setting.

Further information

Please click here for more information.


Thank you for submitting.

We will be in touch within 24 hours

An unexpected error has occurred.

You will need to complete the form again, sorry for the inconvenience.

How can we help?

If you have a medical emergency please call 000. If you have an urgent request and would like to speak to our staff, please contact one of our centres directly.

* Indicates a required field.