2019-01-20T03:00:00.000+11:00

Stereotactic radiosurgery for the treatment of recurrent High-grade Gliomas: long-term follow-up.

Stereotactic radiosurgery for the treatment of recurrent High-grade Gliomas: long-term follow-up.
Cureus 2019, 11 (12): e6527
/es/profesionales-sanitarios/estudios-e-investigacion/publicacion-de-articulos/stereotactic-radiosurgery-for-the-treatment-of-recurrent-high-grade-gliomas-long-term-follow-up

 

Abstract


High-grade gliomas (HGG) are the most frequent primary central nervous system tumors; treatment of HCGs includes surgery and post-operative conformal radiotherapy associated with temozolomide (TMZ or procarbazine/lomustine/vincristine [PCV], specifically in patients with anaplastic oligodendrogliomas or anaplastic oligoastrocytomas). However, recurrence is common. Re-irradiation has been utilized in this setting for years and remains a feasible option, although there is always a concern regarding toxicity. Modern high-precision conformal techniques, including stereotactic radiosurgery (SRS), could improve the therapeutic ratio by delivering high biologically equivalent doses while reducing high-dose radiotherapy (RT) to normal brain tissue. In this paper, we present the results obtained after prolonged follow-up in patients who underwent SRS as a treatment for recurrent high-grade gliomas at San Francisco Hospital in Madrid, Spain.

 

https://pubmed.ncbi.nlm.nih.gov/31911881/