Dr John Slyvester

John E. Sylvester

John E. Sylvester
John E.
Radiation Oncologist

Languages spoken


Expert in

Prostate, bladder and skin cancer


Dr. John Sylvester has performed over 6,000 prostate brachytherapy procedures. He has developed multiple technical improvements in the procedure, by improving visualization of the urethra during the procedure, optimally utilizing R.A.P.I.D. strand, and co-developed THINStrand. He has published numerous articles and medical textbook chapters on prostate brachytherapy and co-authored and edited The Prostate Cancer Treatment Book. He wrote the white paper on 4-D Calypso image guided IMRT and was first physician in USA to use SpaceOAR in prostate cancer IG-IMRT. Dr. Sylvester earned the “Innovation Research Award 2014” from the Manatee County Chamber of Commerce and was awarded Sarasota Magazine’s Top Doctors distinction from 2012-2016. He publishes Prostate cancer research papers every year and regularly lectures at the National Radiation Oncology Society Medical Conferences (ASTRO, ABS).


  • Dr. John Sylvester spoke on ABC7 about the importance of prostate cancer screening and treatment, watch the full interview here.
  • Good Morning America (ABC) 1996
  • Melbourne Australia Local TV 1998
  • Duluth, Minnesota TV 2003
  • KONG, KING, KIRO, KOMO TV January 2007
  • Brazil TV 2007
  • American Public Radio 2007
  • Newspapers in Auckland NZ, Melbourne Australia, Minnesota, London, Seattle, Edmonds, Los Angeles, Freiberg Germany
  • ABC 7 news Sarasota FL Feb 2014
  • WSRQ Talk Radio- News in Prostate Cancer
  • Bay 9 News Tampa- May 22nd 2015 (FDA Approval of SpaceOAR for Radiation in Prostate Cancer)
  • Sarasota Magazine June 2015 article regarding SpaceOAR research and prostate cancer
  • NBC Tampa (8) June 2015 (FDA Approval of SpaceOAR for Radiation in Prostate Cancer)

Career positions

Current position(s)

  • GenesisCare - Radiation Oncologist, Lakewood Ranch, FL
  • Clinical Assistant Professor - Florida State University, College of Medicine

Past position(s)

  • Seattle Prostate Institute - Clinical Research Director (June 2008- July 2009)
  • Seattle Prostate Institute - Medical director (Jan 2001- June 2008)
  • Seattle Prostate Institute - Director - Education/Training (Jan 1997- Jan 2001)
  • Seattle Prostate Institute - Cofounder (July 1988 - July 2009)



  • Undergrad - 9/1975-3/80 UCSB, Santa Barbara, CA, (B.A. Biological Sciences)
  • Medical School - 9/1980-6/84 UCLA, Los Angeles, CA


  • 6/1985-6/88 UCLA Department of Radiation Oncology
  • 6/1987-6/88 Chief Resident


  • 6/1984-6/85 USC, Huntington Memorial Hospital, (Internal Medicine)

Professional associations


Dr. John Sylvester has over 50 presentation and over 80 publications which can be shared upon request, covering various aspects of his clinical expertise.

Awards and honors

  • American Cancer Society Fellowship
  • Manatee Chamber of Commerce Champions of Healthcare Finalist
  • Innovation/Research Award Manatee County
  • Fellow American Brachytherapy Society (FABS)
  • Top Doctors Radiation Oncology Sarasota Magazine (2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020)


  • Transrectal Ultrasound-Guided Prostate Brachytherapy
  • Prostate Brachytherapy Seed Identification On Post-Implant TRUS Images
  • Ten-Year Biochemical Relapse-Free Survival Following External Beam Radiation and Brachytherapy for Localized Prostate Cancer: The Seattle Experience
  • Brachytherapy for Carcinoma of the Prostate: Techniques, Patient Selection, and Clinical Outcomes
  • Brachytherapy as Monotherapy, In Prostate Cancer Principles & Practice


  • Prostate Cancer Comparative Effectiveness
    Dr. John E Sylvester , 2020, Important information for prostate cancer patients
    View Presentation
  • Z101920161
    D. A. Hamstra, N. F. Mariados, D. K. Shah, S. M. Kurtzman, J. E. Sylvester, S. H. Zimberg, R. S. Hudes, L. Karsh, M. D. Logsdon, D. C. Beyer, M. Kos, R. A. Hsi, K. Forsythe, E. M. Soffen, P. M. Francke, H. Zhang, T. L. DeWeese, R. J. Ellis II, C. A. Mantz, W. R. Bosch, and J. M. Michalski;, 2016, ASTRO
  • Z12820161
    Daniel A. Hamstra, Dhiren Shah, Steven Kurtzman, John Sylvester, Shawn H. Zimberg, Richard S. Hudes, LawrenceIvan Karsh, Mark D. Logsdon, David Beyer, Michael Kos, R. Alex Hsi, Kevin Forsythe, Edward M Soffen, Patrick MFrancke, Hong Zhang, Theodore L. DeWeese, Rodney J. Ellis, Jeffrey Bogart, Constantine Mantz, Neil Mariados, 2017, Genitourinary Cancers Symposium

In the media

Dr. John Sylvester of GenesisCare on Prostate Cancer Awareness

September 15, 2022

Listen to podcast

Early Detection & the Right Treatment Critical for Prostate Cancer

December 9, 2022

Read article

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