Dr. Neal D. Shore

  • MD, FACS
  • Urologist
  • Spoken languages English

Overview

Career Positions

Current position(s)

  • GenesisCare, National Urology Research Director, Myrtle Beach, SC

Past position(s)

  • Carolina Urologic Research Center/Grand Strand Urology - Medical Director, Myrtle Beach, SC
  • Urology Oncology Consortium - Founding Member, Myrtle Beach, SC
  • CUSP - Founding Member, Myrtle Beach, SC

Education

Universities

  • Duke University, BA, Public Policy Sciences, Durham, NC
  • Duke University School of Medicine, Durham, NC

Residencies

  • The New York Hospital, Cornell Medical Center, General Surgery, New York, NY
  • The New York Hospital, Cornell Medical Center, Chief Resident, Urology, New York, NY

Expertise And Interests

Expertise

  • Urology, Urologic Surgery

Interests

  • Prostate and Bladder Cancer, Erectile Dysfunction, Voiding Disorders, BPH Trials

Accomplishments

Publications

  • Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer
    Go To Study
  • Combined advanced prostate cancer treatments: are they additive?
    Go To Study
  • Niraparib with androgen receptor‑axis‑targeted therapy in patients with metastatic castration‑resistant prostate cancer: safety and pharmacokinetic results from a phase 1b study (BEDIVERE)
    Go To Study
  • A randomized phase 2 trial of pembrolizumab versus pembrolizumab and acalabrutinib in patients with platinum-resistant metastatic urothelial cancer
  • Optimizing the management of castration-resistant prostate cancer patients: A practical guide for clinicians
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Presentations

HERO phase III trial: Results comparing relugolix, an oral GnRH receptor antagonist, versus leuprolide acetate for advanced prostate cancer.

Neal D. Shore, 2020, ASCO Annual Meeting

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Efficacy of enzalutamide (ENZA) + androgen deprivation therapy (ADT) in metastatic hormone-sensitive prostate cancer (mHSPC) by pattern of metastatic spread: ARCHES post hoc analyses.

Neal D. Shore, 2022, ASCO Annual Meeting

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Phase Ib study: APL-1202 (APL) in combination with Bacillus Calmette-Guerin (BCG) in recurrent non-muscle invasive bladder cancer (NMIBC).

Neal D. Shore, 2020, ASCO Annual Meeting

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Overall survival (OS) results of phase III ARAMIS study of darolutamide (DARO) added to androgen deprivation therapy (ADT) for nonmetastatic castration-resistant prostate cancer (nmCRPC).

Neal D. Shore, 2020, ASCO Annual Meeting

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Pembrolizumab (pembro) plus enzalutamide (enza) in patients (pts) with abiraterone acetate (abi)-pretreated metastatic castration-resistant prostate cancer (mCRPC): KEYNOTE-365 cohort C efficacy, safety, and biomarker results.

Neal D. Shore, 2020, ASCO Annual Meeting

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DaroACT: Darolutamide and enzalutamide effects on physical and neurocognitive function and daily activity in patients with castration-resistant prostate cancer (CRPC).

Neal D. Shore, 2020, ASCO Annual Meeting

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TALAPRO-2: a placebo-controlled phase III study of talazoparib (TALA) plus enzalutamide (ENZA) for patients with first-line metastatic castration-resistant prostate cancer (mCRPC).

Neal D. Shore, 2020, ASCO Annual Meeting

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Pembrolizumab Plus Enzalutamide in Abiraterone-Pretreated Patients with Metastatic Castration-Resistant Prostate Cancer: Updated Results from Keynote-365 Cohort C

Yu, EY, P Fong, JM Piulats, L Appleman, H Conter, S Feyerabend, N Shore, G Gravis, B Laguerre, H Gurney, M Retz, E Romano, L Mourey, JS de Bonno, A Kam, U Emmenegger, H Wu, C Poehlein, and W Berry, 2020, American Urological Association Annual Meeting

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A multicenter phase IIb trial to evaluate the efficacy and tolerability of ModraDoc006/r in subjects with metastatic castration-resistant prostate cancer (mCRPC), suitable for treatment with a taxane (NCT04028388)

Vaishampayan, UN, EJ De Wit, ND Shore, R Dreicer, DJ George, RV Boccia, BD Curti, L Geczi, T Csõszi, and NJ Vogelzang, 2020, Genitourinary Cancers Symposium

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PROTEUS: A randomized, double-blind, placebo (PBO)-controlled, phase III trial of apalutamide (APA) plus androgen deprivation therapy (ADT) versus PBO plus ADT prior to radical prostatectomy (RP) in patients with localized high-risk or locally advanced prostate cancer (PC)

Taplin, M-E, M Gleave, CP Evans, E Efstathiou, PW Kantoff, A Ross, ND Shore, A Briganti, BA Hadaschik, A Heidenreich, OB Rooney, SK Tian, L Wetherhold, W Xu, S Cheng, SD Brookman-May, A Lopez-Gitlitz, and AS Kibel, 2020, Genitourinary Cancers Symposium

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Concurrent or layered treatment (Tx) with radium-223 (Ra-223) and enzalutamide (Enza) or abiraterone plus prednisone/prednisolone (Abi/pred): A retrospective study of real-world clinical outcomes in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)

Shore, ND, OA Sartor, CN Sternberg, F Saad, BF Tombal, K Miller, J Kalinovsky, X Jiao, K Tangirala, and CS Higano, 2020, Genitourinary Cancers Symposium

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An open-label phase Ib study of ORIC-101 in combination with enzalutamide in patients with metastatic prostate cancer progressing on enzalutamide

Shore, ND, R Patel, R Xu, PS Multani, Michael J. Morris, and W Abida, 2020, Genitourinary Cancers Symposium

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Review of the real-world prevalence of mHSPC, nmCRPC, mCRPC, and gene alterations associated with HRR in prostate cancer (PC)

Shore, ND, L Oliver, I Shui, A Gayle, OY Wong, J Kim, S Payne, and SR Ghate, 2020, Genitourinary Cancers Symposium

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Integrating comprehensive genomic profiling into the clinical management of prostate cancer patients: A single institution community practice experience

Shore, ND, J Haberberger, EA Severson, P Sathyan, P Reddy, and SH Ramkissoon, 2020, Genitourinary Cancers Symposium

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Phase III study of pembrolizumab (pembro) plus docetaxel and prednisone for enzalutamide (enza)- or abiraterone acetate (abi)–pretreated patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): KEYNOTE-921

Shore, ND, Mostefa Bennamoun, R Ratta, JM Piulats, B Li, C Schloss, and K Fizazi, 2020, Genitourinary Cancers Symposium

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HERO Phase 3 Trial: Results Comparing Relugoliz, an Oral GNRH Receptor Antagonist, vs Leuprolide Acetate for Advanced Prostate Cancer

Shore, N, F Saad, M Cookson, DJ George, DR Saltzstein, R Tutrone, H Akaza, A Bossi, D van Veenhuyzen, B Selby, X Fan, V Kang, J Walling, and B Tombal, 2020, American Urological Association Annual Meeting

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Phase 3 Results of Vicinium in BCG-Unresponsive Non-Muscle Invasive Bladder Cancer

Shore, N, M O’Donnell, T Keane, MAS Jewett, GS Kulkarni, R Dickstein, F Wolk, C Dunshee, L Belkoff, RL Dillon, J Cizeau, and W Kassouf, 2020, American Urological Association Annual Meeting

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Impact of Baseline Disease Volume and Prior Docetaxel Therapy on Prostate-Specific Antigen-Related Outcomes in Patients with Metastatic Hormone-Sensitive Prostate Cancer Treated with Enzalutamide Plus Androgen Deprivation Therapy

Shore, N, ED Crawford, RZ Szmulewitz, D Petrylak, J Holzbeierlein, A Villers, A Azad, A Alcaraz, B Alekseev, T Iguchi, F Gomez-Veiga, B Rosbrook, B Baron, GP Haas, A Stenzl, and AJ Armstrong, 2020, American Urological Association Annual Meeting

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Prostate Cancer Active Surveillance Quality in Large Community Urology Practices

Shelton, J, E Wood, T Paivanas, P Buffington, S Ruyle, E Cohen, R Natale, B Mehlhaff, R Suh, T Bradford, A Koo, L Kwan, and N Shore, 2020, American Urological Association Annual Meeting

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Phase Ib study of niraparib plus androgen receptor-targeted therapy (ART) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)

Saad, F, KN Chi, ND Shore, JN Graff, EM Posadas, BM Espina, E Zhu, A Hazra, B Bradic, S Cheng, V Hayreh, and A Rezazadeh, 2020, Genitourinary Cancers Symposium

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A comparison of sipuleucel-T (sip-T) product parameters from two phase III studies: PROVENT in active surveillance prostate cancer and IMPACT in metastatic castrate-resistant prostate cancer (mCRPC)

Ross, A, AJ Armstrong, Christopher M Pieczonka, JL Bailen, RF Tutrone, MR Cooperberg, CP Pavlovich, JF Renzulli, H Haynes, NA Sheikh, and ND Shore, 2020, Genitourinary Cancers Symposium

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The association of humoral antigen spread (AgS) with cytotoxic T lymphocyte (CTL) activity after sipuleucel-T (sip-T) treatment in two phase II clinical studies: STAMP and STRIDE

Petrylak, DP, ES Antonarakis, H Kandadi, L Fong, RS Lance, T Vu, NA Sheikh, ND Shore, and CG Drake, 2020, Genitourinary Cancers Symposium

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Next-generation sequencing (NGS) of tumor tissue from >4000 men with metastatic castration-resistant prostate cancer (mCRPC): The PROfound phase III study experience

Hussain, MHA, J Mateo, SK Sandhu, K Fizazi, F Saad, ND Shore, D Olmos, C Corcoran, C Sibilla, A Kohlmann, CA Adelman, JA Elvin, CD Goessl, J Burgents, and JS De Bono, 2020, Genitourinary Cancers Symposium

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Can TURBT be Avoided? Primary Chemoablation with a Reverse Thermal Gel Containing Mitomycin (UGN-102) in Patients with Low Grade Intermediate Non-Muscle Invasive Bladder Cancer

Huang, W, K Chevli, A Trainer, A Smith, D Saltzstein, Y Ehrlich, B Friiedman, R D’Anna, D Morris, B Hu, M Tyson, A Sankin, M Kates, J Linehan, D Scherr, S Kester, M Verni, K Chemie, L Karsch, A Cinman, E Seltzer, N Gabai, R Kirshoff, M Schoenberg, J Raman, and N Shore, 2020, American Urological Association Annual Meeting

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Clinical outcomes and patient (pt) profiles in REASSURE: An observational study of radium-223 (Ra-223) in metastatic castration-resistant prostate cancer (mCRPC)

Higano, CS, F Saad, AO Sartor, K Miller, P Conti, DJ George, CN Sternberg, ND Shore, JP Sade, J Bellmunt, MR Smith, C Logothetis, F Verholen, J Kalinovsky, I Bayh, and BF Tombal, 2020, Genitourinary Cancers Symposium

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Phase III study of perioperative pembrolizumab (pembro) plus cystectomy versus cystectomy alone in cisplatin-ineligible patients (pts) with muscle-invasive bladder cancer (MIBC): KEYNOTE-905

Galsky, MD, A Necchi, ND Shore, F Witjes, K Nam, E Sbar, B Homet Moreno, and ER Plimack, 2020, Genitourinary Cancers Symposium

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PROfound: Efficacy of olaparib (ola) by prior taxane use in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) and homologous recombination repair (HRR) gene alterations

De Bono, JS, K Fizazi, F Saad, ND Shore, G Roubaud, M Ozguroglu, N Penel, N Matsubara, N Mehra, G Procopio, MP Kolinsky, K Nishimura, S Feyerabend, JY Joung, NJ Vogelzang, MA Carducci, J Kang, CH Poehlein, W Wu, and MHA Hussain, 2020, Genitourinary Cancers Symposium

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KEYNOTE-365 cohort C updated results: Pembrolizumab (pembro) plus enzalutamide (enza) in abiraterone (abi)-pretreated patients (pts) with metastatic castrate-resistant prostate cancer (mCRPC)

Berry, WR, PCC Fong, JM Piulats, LJ Appleman, HJ Conter, S Feyerabend, ND Shore, G Gravis, B Laguerre, H Gurney, M Retz, E Romano, L Mourey, JS De Bono, AE Kam, U Emmenegger, Helen Wu, Charles Schloss, Christian Heinrich Poehlein, and Evan Y. Yu, 2020, Genitourinary Cancers Symposium

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TALAPRO-2: A placebo-controlled phase III study of talazoparib (TALA) plus enzalutamide (ENZA) for patients with first-line metastatic castration-resistant prostate cancer (mCRPC)

Agarwal, N, ND Shore, C Dunshee, LI Karsh, A Azad, AP Fay, J Carles, B Sullivan, N Di Santo, M Elmeliegy, X Lin, RGW Quek, A Czibere, and K Fizazi, 2020, Genitourinary Cancers Symposium

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Lower ut symptoms due to benign prostatic hyperplasia

Shore, N.D., ,

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Francisco A. Myslicki, Jesse Shulman, Sharon Salenius, Neal Shore, Constantine Mantz, Eduardo Fernandez, Steven E. Finkelstein, 2015, ARS

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Neal D. Shore, 2016, E-Cancer TV

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Neal D. Shore, 2017, LUGPA

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Neal D. Shore, 2018, Urology Today

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Myslicki FA, Salenius SA, Shore ND, Mantz CA, Fernandez E, Finkelstein SE, 2015, ACRO Annual Meeting

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