177Lutetium PSMA therapy, or Prostate-Specific Membrane Antigen therapy, is an innovative molecular therapy used to treat advanced prostate cancer. It precisely targets cancerous cells, avoiding damage to surrounding healthy tissue.
 

How does 177Lutetium PSMA therapy work?

 
177Lutetium PSMA therapy uses a molecule which attaches itself to the PSMA receptors on the cancer cells. Before it’s given, the PSMA molecule is bound with 177Lutetium, a radioactive substance that damages and destroys prostate cancer cells in a targeted way. The PSMA molecule carries the 177Lutetium straight to the tumour site so the whole body isn’t exposed to radiation.

 

What are the benefits of 177Lutetium PSMA therapy?

This therapy helps:

  • Reduce the size of the tumour and stop it growing
  • Improve the symptoms caused by the tumour
  • Maintain and improve quality of life

After treatment, some patients have a long period of remission and significant improvements in their quality of life.

When would I consider this treatment for my patient?

This therapy is most often used when prostate cancer has metastasised and when other therapies are poorly tolerated or have failed. In certain patients, it appears to be able to produce long term remission.
 
 

Before the patient starts treatment they will have a diagnostic GA-68 PSMA PET/CT scan to help identify the location of the cancer. This also helps in staging and planning of treatment.

If the PET/CT scan shows that the patient could benefit from 177Lutetium therapy they will be offered an appointment to discuss what’s involved. We may also ask them to complete a short questionnaire about their general health to help assess whether this treatment is right for them.

Therapy is delivered as an outpatient procedure at our Theranostics suite in Windsor. On the day of treatment the radioactive 177Lutetium will be injected, followed by 1-2 litres of saline. Each cycle is delivered over four hours via a drip inserted into a vein in the arm. The treatment cycle is usually cyclical and normally involves four treatments carried out 6 – 8 weeks apart. Most people have four to six cycles of treatment.

Therapy is personalised according to response and symptoms. Blood tests are carried out before each cycle to check how well things are going.

We will arrange follow up appointments before the patient leaves the department.

Like all cancer treatments, there can be side-effects. These vary from person to person, but may include:

  • Dry mouth
  • Tiredness
  • Mild nausea
  • Loss of appetite

Some patients may produce fewer blood cells than normal for a while. But they’ll be offered regular blood tests to check everything’s OK. We’ll help find ways to reduce and manage any side-effects including medication to reduce any symptoms.

Before the patient starts treatment they will have a diagnostic GA-68 PSMA PET/CT scan to help identify the location of the cancer. This also helps in staging and planning of treatment.

If the PET/CT scan shows that the patient could benefit from 177Lutetium therapy they will be offered an appointment to discuss what’s involved. We may also ask them to complete a short questionnaire about their general health to help assess whether this treatment is right for them.

Therapy is delivered as an outpatient procedure at our Theranostics suite in Windsor. On the day of treatment the radioactive 177Lutetium will be injected, followed by 1-2 litres of saline. Each cycle is delivered over four hours via a drip inserted into a vein in the arm. The treatment cycle is usually cyclical and normally involves four treatments carried out 6 – 8 weeks apart. Most people have four to six cycles of treatment.

Therapy is personalised according to response and symptoms. Blood tests are carried out before each cycle to check how well things are going.

We will arrange follow up appointments before the patient leaves the department.

Like all cancer treatments, there can be side-effects. These vary from person to person, but may include:

  • Dry mouth
  • Tiredness
  • Mild nausea
  • Loss of appetite

Some patients may produce fewer blood cells than normal for a while. But they’ll be offered regular blood tests to check everything’s OK. We’ll help find ways to reduce and manage any side-effects including medication to reduce any symptoms.

Easy Access

Cancer care at GenesisCare may be covered by private medical insurance – we’re recognised by most major insurers. We also offer a range of self-pay packages.

Theranostics is offered at our Windsor centre.

How to refer a patient

Please send a referral/clinic letter to windsor.enquiries@genesiscare.com

For more information

Contact us directly
Tel: 01753 418 444
Email: theranosticsUK@genesiscare.co.uk

Meet Dr Yong Du

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Maidstone

17 Kings Hill Avenue, Kings Hill, West Malling, ME19 4UA

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Little Aston Hall Drive, Sutton Coldfield, B74 3BF

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The Park Centre for oncology, Sherwood Lodge Drive, Burntstump Country Park, Nottingham, NG5 8RX

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Bartons Road, Havant, PO9 5NA

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BMI St Martha Oncology Centre, 46 Harvey Road, Guildford, GU1 3LX

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Spire Hospital, Chalybeate Close, Southampton, SO16 6UY

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Springfield Cancer Centre, Lawn Lane, Chelmsford, CM1 7GU

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Unit 710, Centennial Park, Centennial Avenue, Elstree, Borehamwood, WD6 3SZ

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Sandy Lane West, Peters Way, Oxford, OX4 6LB

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Sunrise Parkway, Linford Wood East, Milton Keynes, MK14 6LS

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The Oaks, Fordham Road, Newmarket, CB8 7XN

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Windsor

69 Alma Road, Windsor, SL4 3HD

windsor.enquiries@genesiscare.com

 

Who may benefit?

 
Theranostics can be used to treat cancers that have spread (metastasised), or where cancer is advanced and/or hasn’t responded to other treatments.

While in the future theranostics may be used for different cancers, to date most experience and success has been in metastatic prostate cancer and neuroendocrine tumours.
 

Metastatic prostate cancer

 
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How it works

 
Theranostics is a personalised approach to treating cancer, using both diagnosis and therapy tools as part of the treatment.

Theranostics uses PET scan imaging (a special type of scan) to see if specific targets, known as tumour receptors, are present on tumour cells. If these targets are present and visible on the scan, a radioactive drug is used to treat the tumours. The drug is given as an injection and selectively targets the tumour cells while avoiding healthy areas. Most of the radioactive drug that doesn’t reach the target is quickly passed out of the body.

 
 
 

 

Theranostics is not suitable for all patients, but may be an option in metastatic disease unresponsive to or unsuitable for conventional therapies. Most evidence to date is in metastatic castrate resistant prostate cancer and advanced neuroendocrine tumours (NETs).

  • A Phase 2 study (n=30) of 177Lu-PSMA-617 showed ‘high response rates, low toxicity effects, and a reduction in pain in men with metastatic castration-resistant prostate cancer who have progressed after conventional treatments’1.
  • In Phase 3 study, NETTER–1*, ’177Lu-Dotatate resulted in markedly longer progression-free survival than high-dose octreotide LAR and was associated with limited acute toxic effects in a population of patients who had progressive neuroendocrine tumours that originated in the midgut’2.

 

Available services

  • 177Lutetium PSMA – for Metastatic or Treatment Resistant Prostate Cancer
  • 177Lutetium Octreotate – for somatostatin receptor – positive tumours (available from Autumn 2019)

Easy access

 
Cancer treatment at GenesisCare may be covered by insurance. We also offer self-pay options for Theranostics.

How to refer a patient

Please send a referral/clinic letter to windsor.enquiries@genesiscare.com

For more information

Contact us directly
Tel: 01753 418 444
Email: theranosticsUK@genesiscare.co.uk

1. Hofman, et al. Lancet Oncol; 2018; 19: 825–33
2. Strosberg, et al. N Engl J Med; 2017; 376: 125-135

 

What is PBMT?

 
PBMT uses a low-intensity laser beam aimed at various parts of your mouth, helping to reduce Oral mucositis (OM) which is when the lining of your mouth becomes inflamed – a common side effect of radiotherapy and chemo-radiotherapy treatment for head & neck cancer.

OM can be painful. You may have difficulty swallowing. You may also lose weight. In some cases, you might need to have additional medication, or even a feeding tube, as well as more frequent appointments with your multidisciplinary head & neck team.

How can PBMT help?

 
PBMT is an effective treatment that can reduce the severity and duration of OM. It’s been used for more than 20 years to help reduce this side-effect in patients with head & neck cancers.

It can help by:

  • Encouraging the tissues inside the mouth to heal
  • Reducing inflammation and risk of ulcers
  • Enabling you to swallow more comfortably
 
 

  • Reducing pain (so you don’t need to take as much pain relief medicine)
  • Making it less likely that you’ll need to be fed via a tube
  • Improving your quality of life

How does PBMT work with my radiotherapy treatment?

 
You’ll receive your first PBMT treatment a couple of hours before your first radiotherapy session. Then around 30 minutes before all other radiotherapy sessions. It’s delivered by specially trained PBMT radiographers and takes approximately 30 minutes. You will be asked to wear goggles to ensure your eyes are protected during each treatment.

We advise that you should avoid alcohol and not smoke throughout the course of your treatment. We also provide access to a dietician to assist you.

Are there any side-effects from PBMT?

 
PBMT is painless, and there are no known side-effects.

Where can you have PBMT?

You can be treated with PBMT at our Southhampton centre:

Spire Hospital, Chalybeate Close, Southampton, SO16 6UY

Telephone: 0238 189 0624
Email: southampton.enquiries@genesiscare.com

We have free on-site parking.

Learn more

Meet our doctors

Everything we do is focused on designing better care for our patients. With a network of 12 specialist oncology treatment centres across the UK, we provide the most up-to-date treatments and technology as standard.

We attract and retain some of the most experienced doctors in the country, who all have a passion for improving patient outcomes and specialise in the treatment of different types of cancer.

Meet our doctors

 

Before your treatment begins, you’ll be offered a PET/CT scan. The scan helps us identify cancerous targets called tumour receptors so we can precisely plan your treatment.

What is a PET/CT Scan?

A PET/CT scan combines two imaging techniques: Positron Emission Tomography (PET) and Computerised Tomography (CT). PET produces 3-D images of your body and allows us to look at your metabolism and other important functions. We can also study any changes that are happening over time while we monitor your condition. The CT scan uses computer-processed X-ray measurements to create a detailed image.

How does it work?

Before carrying out a PET/CT scan, a ‘tracer’ (a type of radioactive substance) will be injected in to your arm, hand, or foot. The tracer spreads through the body and gives off a type of radiation that shows up on the PET scan. This allows the scanner to build up a detailed image that identifies areas of the body affected by disease, as well as some of the body’s functions.

The PET scans are combined with CT scans which adds the precision of anatomic localisation to functional imaging enabling a more accurate diagnosis. The CT scanner takes a series of cross-sectional images (‘slices’) and then computer processing is used to construct a three-dimensional image.
 

Using this method, we can get important information about many conditions affecting different parts of the body. The combination of scans shows the precise shape, location and size of your tumour. It helps your specialist to make an accurate diagnosis and plan the best treatment for you. The scan is safe and doesn’t hurt.

Having a PET/CT scan

A radiographer will ask you to lie on the scanner bed and make you as comfortable as possible. The scanner bed will move gently and slide you into the centre of the scanner until the part of the body to be scanned is correctly positioned. While the scan is taking place, you’ll need to remain still.

The scan takes between 20 and 45 minutes but there’s also some preparation time, so you’ll need to allow about two hours for the appointment.

Side-effects

The amount of radioactivity injected in the tracer is relatively small and will be excreted by your kidneys (passed when you urinate). It will not produce any side effects. You can eat, drink and travel as normal after the test. However, as a precaution, we advise our patients to avoid having close contact with young children and pregnant women for 4 – 6 hours after leaving the department.

The test is not advised if you are pregnant or are breast feeding.

Philip's experience of a PET/CT scan

Find out more

For more information about a private PET/CT scan at GenesiscCare please call:

Oxford:01865 706 098

Windsor: 01753 343 213

Or complete the enquiry form below and we’ll come back to you – usually within 24 hours

 

Make an enquiry